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Adverse events in childhood have been linked to an increase in the likelihood of developing lung cancer in later life. Researchers writing in the open access journal BMC Public Health describe how the link is partly explained by raised rates of cigarette smoking in victims of childhood trauma, but note that other factors may also be to blame.
David Brown and Robert Anda, from the Centers for Disease Control and Prevention, Atlanta, USA, worked with a team of researchers to study the effects of abuse (emotional, physical, sexual), witnessing domestic violence, parental separation, or growing up in a household where people were mentally ill, substance abusers, or sent to prison. He said, “Adverse childhood experiences were associated with an increased risk of lung cancer, particularly premature death from lung cancer. Although smoking behaviours, including early smoking initiation and heavy smoking, account for the greater part of this risk, other mechanisms or pathophysiologic pathways may be involved”.
Adverse event information was collected from 17,337 people between 1995 and 1997. Brown and his colleagues followed up on the medical records of these same people to study lung cancer rates in 2005. According to Brown, “Compared to those who claimed no childhood trauma, people who experienced six or more traumas were about three times more likely to have lung cancer, identified either through hospitalization records or mortality records. Of the people who developed, or died of, lung cancer, those with six or more adverse events in childhood were roughly 13 years younger at presentation than those with none. People who had experienced more adverse events in childhood showed more smoking behaviors”.
The central message of this study is that our children can be faced with a terrible burden of stressors. These stressors are associated with harmful behaviours, such as smoking, that may lead the development of diseases like lung cancer and perhaps death at younger ages. Reducing the burden of adverse childhood experiences should therefore be considered in health and social programs as a means of primary prevention of lung cancer and other smoking-related diseases.
Recently, Celgene Corporation (NasdaqGS: CELG – News) completed the acquisition of the privately held Gloucester Pharmaceuticals for $340 million in cash coupled with $300 million in future milestone payments. The deal is aimed at bolstering Celgene’s portfolio of cancer drugs. The deal is expected to be neutral to Celgene’s earnings in 2010 and accretive in 2011…. (more…)
Actor Michael C. Hall, who plays a serial killer in the TV seriesDexter,said this week that he has been battling cancer but the treatment is almost finished and the disease is in remission…. (more…)
Showtime’s Nick Charles, the blow-by-blow announcer on “ShoBox: The New Generation” since the series’ inception in 2001, is returning to ringside after battling bladder cancer since August, the network announced.
Charles was diagnosed with stage IV urothelial carcinoma over the summer but announced Friday that he is 80 percent in remission and that his doctors have given him the go-ahead to resume working.
He will be back on the air for the Jan. 29 “ShoBox,” which is will be headlined by bantamweight prospect Chris Avalos facing Jose Nieves at the Tingley Auditorium in Albuquerque, N.M., working with analysts Steve Farhood and Antonio Tarver. Charles turns 64 the following day.
“I never really lost hope and faith that I’d be back on ‘ShoBox’ working with the finest people I know professionally and personally,” Charles said. “The boxing community has been overwhelmingly supportive. Their inspiration has moved me deeply. As important to me though are the fans of ‘ShoBox’ who have expressed to me beyond all expectations their concern and encouragement through a difficult illness.”
During Charles’ absence, Al Bernstein, who pulled double duty while also working as an analyst on “Showtime Championship Boxing,” and Curt Menefee filled in.
“We are thrilled to announce the return of Nick Charles to ‘ShoBox,’” said Showtime’s Ken Hershman, who heads the network’s sports division. “Nick is one of the great guys in our business. His strength and perseverance through this ordeal has inspired all of us. We continue to offer our support and love and we look forward to Jan. 29 when Nick returns to the mic.”
Charles, who was treated at University of Texas M.S. Anderson Cancer Center in Houston, has been off “ShoBox” since July 31, although Top Rank hired him to call the international telecast of the Manny Pacquiao-Miguel Cotto fight on Nov. 14…. (more…)
A Greencastle breast cancer survivor reveals how her Christian faith helped her get through the journey of her cancer diagnosis and treatment in her recently published book, “He Provides the Shoes: Walking with God Through Breast Cancer.”
Karen Holmes was 43 when she was diagnosed with an aggressive type of breast cancer in February 2006.
“With no family history of the disease and a healthy lifestyle — including regular exercise and a healthy diet low in saturated fat — I was very surprised about my cancer diagnosis,” said Holmes who is the mother of young daughters and had worked as a nurse. Her husband, Dr. Brian Holmes, is a neurosurgeon.
The book is a detailed journal of her two years of cancer treatments. She had a lumpectomy followed by four months of potent chemotherapy and then a year of less toxic chemotherapy that included the drug Herceptin, which is designed for those who are HER-2 positive (25 percent of breast cancer victims are HER-2 positive).
An evangelical Christian, Holmes kept a journal of what she was feeling during those two years. It included her relationship with Jesus Christ, her Protestant faith and her family.
Holmes’ experiences with breast cancer helped her realize how much she needs God.
“When you’re frightened and caught off guard, God will walk with you every step of the way,” the author said.
and try to encourage others, too,” she said….. (more…)
Bionovo, Inc announced the publication of their results from its phase-1B clinical trial of Bezielle (BZL101) for metastatic breast cancer. The results of the study are available online in Breast Cancer Research and Treatment and demonstrate that Bezielle continues to be safe and well tolerated with clinical evidence of anticancer activity in a heavily pretreated population of women diagnosed with metastatic breast cancer. Preliminary results from this study were released previously by the Company.
The purpose of the phase-1B clinical trial was to identify the maximum tolerated dose of Bezielle and to determine the safety and feasibility of the company’s novel, oral, anticancer treatment. A total of 27 women with late stage breast cancer were enrolled to the phase-1B trial. The 27 enrolled women had failed an average of six prior therapies since diagnosis with metastatic breast disease and expected survival pre-trial was 90-120 days. To date, a total of 48 women with advanced breast cancer have been treated with Bezielle in two early phase clinical trials.
“We are encouraged by the results of the Company’s second phase-1 trial in women with advanced breast cancer and feel the oncology community is equally enthusiastic about Bezielle as our manuscript was accepted by the most widely read breast cancer specific peer reviewed journal in two days,” said Mary Tagliaferri, president and chief medical officer of Bionovo. “There are currently over 160,000 women in the United States living with advanced breast cancer who are eagerly awaiting an oral anticancer drug that can extend life without profoundly diminishing quality of life. We believe Bezielle will be an important new anticancer agent because its biological selectivity allows the drug to kill cancer cells without affecting normal cells resulting in dramatically fewer side effects.”
“In the age of sequential monotherapy as the treatment approach for women with metastatic breast cancer, Bezielle is one of the most exciting new therapies under investigation today,” said Banu Arun, Department of Breast Medical Oncology, Division of Cancer Medicine, University of Texas, Anderson Cancer Center, Houston, Texas. “At our center, where over 3,000 women are newly diagnosed with breast cancer each year, there is great patient demand for oral drugs with minimal toxicities for the treatment of any stage breast cancer. Bezielle is the exact type of drug our patients are seeking and the favorable clinical results in Bionovo’s two early stage clinical trials among a heavily pretreated patient population are extremely encouraging.”
“While safety and maximum tolerability were the primary endpoints of this second phase 1 trial, Bezielle demonstrated promising clinical efficacy in both phase 1 trials affording some women with long periods of stable disease without dramatically altering their day to day quality of life, which is a significant advancement,” said Alejandra Perez, director of the Breast Cancer Center at the Memorial Regional Hospital Cancer Institute, Hollywood, Florida….
Diabetes interferes with the way the body processes the sugar glucose, the body’s main source of energy. When all is going well, cells absorb glucose from the blood stream after we’ve eaten and use it as fuel, or pack it away for future use. Insulin, produced by the pancreas, orchestrates the process. With diabetes, the process breaks down, and glucose start to builds up in the blood.
There are three types of diabetes:
- Type 1, usually diagnosed in children and adolescents, is caused when the body can’t produce insulin. The body’s immune system or environmental factors are believed to trigger Type 1, which accounts for 10 per cent of diabetes….. (more…)
An estimated 55 million Americans were infected with the H1N1 swine flu from the time the disease first emerged in mid-April until mid-December, and about 11,200 people died, according to official figures.
The flu, which is no longer causing widespread activity after peaking in November in 48 states, has also led to an estimated 246,000 hospitalisations, according to statistics from the US Centres for Disease Control and Prevention.
Although swine flu infections are declining, health officials stress that there could be a resurgence of the disease. So they’re urging people to get vaccinated against the H1N1 virus, especially since vaccine supplies are now plentiful….. (more…)
About 11,000 Americans have died of swine flu as of last month, the Centers for Disease Control and Prevention said. The agency’s previous estimate — for deaths from April, when the virus was discovered, to mid-November — was about 10,000. Because the second wave peaked in late October, the number is unlikely to rise much unless there is a third wave later this winter. The estimate by the World Health Organization as of Jan… (more…)
